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Abstract: Sodium hyaluronate plus diquafosol

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  • Abstract: Sodium hyaluronate plus diquafosol

    Clinical evaluation of the additive effect of diquafosol tetrasodium on sodium hyaluronate monotherapy in patients with dry eye syndrome: a prospective, randomized, multicenter study.

    Purpose
    To assess the additive effect of diquafosol tetrasodium on sodium hyaluronate monotherapy in patients with dry eye syndrome.

    Methods
    This study evaluated 64 eyes of 32 patients (age: 62.6±12.8 years (mean±SD)) in whom treatment with 0.1% sodium hyaluronate was insufficiently responsive. The eyes were randomly assigned to one of the two regimens in each patient: topical administration of sodium hyaluronate and diquafosol tetrasodium in one eye, and that of sodium hyaluronate in the other. Before treatment, and 2 and 4 weeks after treatment, we determined tear volume, tear film break-up time (BUT), fluorescein and rose bengal vital staining scores, subjective symptoms, and adverse events.

    Results
    We found a significant improvement in BUT (P=0.049, Dunnett test), fluorescein and rose bengal staining scores (P=0.02), and in subjective symptoms (P=0.004 for dry eye sensation, P=0.02 for pain, and P=0.02 for foreign body sensation) 4 weeks after treatment in the diquafosol eyes. On the other hand, we found no significant change in these parameters after treatment in the control eyes.

    Conclusions
    In dry eyes, where sodium hyaluronate monotherapy was insufficient, diquafosol tetrasodium was effective in improving objective and subjective symptoms, suggesting its viability as an option for the additive treatment of such eyes.
    Eye (Lond). 2012 Aug 10. doi: 10.1038/eye.2012.166. [Epub ahead of print]
    Kamiya K, Nakanishi M, Ishii R, Kobashi H, Igarashi A, Sato N, Shimizu K.
    Source
    Department of Ophthalmology, University of Kitasato School of Medicine, Kanagawa, Japan.
    Rebecca Petris
    The Dry Eye Foundation
    dryeyefoundation.org
    800-484-0244
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