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Lacrimera Chitosan-N-Acetylcysteine C-NAC

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  • Lacrimera Chitosan-N-Acetylcysteine C-NAC


    Compared to baseline, both the dry eye symptoms intensity score and the Ocular Surface Disease Index were reduced by 55% and 47%, respectively at week 6 and by 67% (right eye) and 78% (left eye) and 70% at Week 26, respectively (p<0.0001).
    Conclusion: Once-daily use of C-NAC eye drops is a highly effective and convenient treatment option for dry eye disease. C-NAC can be safely used long term.
    C-NAC eye drops exhibit extended ocular surface residence time, and in the rabbit were retained in the eye for 48 h after instillation.
    In DED patients, a single instillation of C-NAC eye drops increased tear film thickness (TFT) by 25-30% over 24 h [13]. Similar effect was observed after both once- or twice-daily dosing over five days
    In 2014, a sterile, preservative-free formulation of C-NAC eye drops (Lacrimera®, CROMA-PHARMA GmbH, Leobendorf, Austria) was approved in Europe as a class III medical device for alleviation of dry eye symptoms.
    In conclusion, C-NAC eye drops is a novel, once-daily treatment option for attenuation of symptoms in patients with mild-to-moderate DED. Owing to unique mechanism of action, which involves the formation of an artificial glycocalyx–like structure(protection shield) on the ocular surface, high effectiveness is achieved with once-daily use only. Such simple, convenient and unprecedented dosing regimen for a topical product for DED facilitates patient compliance with dosing instructions and further differentiates C-NAC eye drops from tear substitutes. In view that compliance is the major driver of successful tear film stabilization, C-NAC eye drops represent a significant step forward in the treatment of DED.
    see " Long-term management of dry eye by once-daily use of Chitosan-N-Acetylcysteine (Lacrimera®) eye drops.":
    http://www.alliedacademies.org/artic...rops-9861.html

  • #2
    Where can you purchase these?

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    • #3
      i think it's not on the market yet.but may be it will be in Europe before lacripep.

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