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"Sylentis’ dry eye disease (DED) drug tivanisiran has failed Phase III"

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  • "Sylentis’ dry eye disease (DED) drug tivanisiran has failed Phase III"

    "Sylentis’ dry eye disease (DED) drug tivanisiran has failed to meet the primary objectives of a Phase III clinical trial investigating its effectiveness.

    The ‘Helix’ study, which compared the tivanisiran-based eye drop siRNA to artificial tears, found there was no statistically significant difference between the two treatments in terms of reducing ocular pain and total corneal staining.

    The study included 330 patients, and was undertaken across location in Spain, Germany, Estonia, Portugal, Slovakia and Italy.

    Professor José Manuel Benítez del Castillo, the study’s principal investigator said finding a solution to DED is important. “Tivanisiran could be a therapeutic alternative for these patients as it is a drug with a new mechanism of action.”

    There were some positive findings in the report. A statistically significant improvement was observed in central corneal staining. According to medial news website FierceBiotech.com, if this result can be reproduced tivanisiran may be effective at improving a particular part of the cornea."

    https://www.insightnews.com.au/Artic...hase-III-study


  • #2
    And another one bites the dust :-(
    Yet another post-Lasik (2005)...
    Anyone have a time machine so I can go back and undo this mess?

    Comment


    • #3
      I was feeling really frustrated and angry yesterday (due to - you guessed it - my eye problems).

      Anyways, my previous post (above) wasn't exactly constructive. So, in an attempt to add some balance, here is an article (published Feb 2019) that may be of interest, it discusses some some treatments that are being looked at: https://www.reviewofophthalmology.co...r-cure-dry-eye <- some are old ones we already know about, but some are new.
      Yet another post-Lasik (2005)...
      Anyone have a time machine so I can go back and undo this mess?

      Comment

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