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PRG4 By Lubris BipPharma

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  • PRG4 By Lubris BipPharma


    Another agent still in the pipeline;

    Lubricin, or known as (PRG4) which is naturally found on the ocular surface, may play an important role in eye health and comfort by preventing friction between the cornea and conjunctiva which reduces shear stress (such as during eye blinking) to prevent eye injury at the corneal and ocular surface. In patients suffering from moderate to severe dry eye, lubricin is diminished and the act of blinking causes significant discomfort.

    Lubricin may be an extremely important barrier to the development of ocular surface damage, such as occurs in dry eye disease (eg.,aging, Sjögren’s syndrome, refractive surgery & contact lens wear). Topical administration of recombinant human lubricin may alleviate the shear stress (friction) that occurs in dry eye disease preventing the onset of inflammation and greatly improving patient quality of life.

    Topical administration of recombinant human lubricin may provide superior reduction in the signs and symptoms of dry eye disease compared to existing treatments by preventing friction and wear on the ocular surface and restoring homeostasis to the tear film.