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Systemic contact dermatitis to corticosteroids

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  • Systemic contact dermatitis to corticosteroids

    [url]http://www.ncbi.nlm.nih.gov/pubmed/23033862[url]

    Allergy. 2012 Oct 4. doi: 10.1111/all.12041. [Epub ahead of print]

    Systemic contact dermatitis to corticosteroids.

    Baeck M, Goossens A.

    Source

    Department of Dermatology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.

    Abstract

    BACKGROUND:
    Although unexpected and paradoxical, allergic hypersensitivity to corticosteroids is a common finding, delayed-type reactions being much more frequently encountered than the immediate-type ones. Although the skin is the main sensitization and elicitation route, other routes, amongst them systemic administration of corticosteroids may exceptionally be involved.

    OBJECTIVE:
    To determine the frequency, clinical presentation and cross-reactivity patterns for allergic reactions following systemic administration of corticosteroids amongst patients with identified and investigated 'contact allergy' to corticosteroids.

    METHODS:
    We reviewed clinical data, patch test results and sensitization sources in patients who reacted positively to corticosteroids tested in the K.U. Leuven Dermatology department during an 18-year period.

    RESULTS:
    Sixteen subjects (out of 315 with CS delayed-type hypersensitivity) presented with allergic manifestations due to systemic administration of corticosteroids. Most patients reacted to molecules from the three groups of the recently reappraised classification.

    CONCLUSION:
    The reactions observed seem to be in most cases 'systemic contact dermatitis' due to oral or parenteral re-exposure of sensitized individuals with the respective corticosteroids previously applied topically. Moreover, most patients seem to be able to react to any corticosteroid molecules and therefore need a systematic individualized evaluation of their sensitization/tolerance profile.

    PMID:

    23033862

    [PubMed - as supplied by publisher]
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