No announcement yet.

LDN / Low Dose Naltrexone

This topic is closed.
  • Filter
  • Time
  • Show
Clear All
new posts

  • LDN / Low Dose Naltrexone

    After reading about LDN here, I started asking around about it. I spoke to my naturopath, my general practitioner, as well as someone here who is well-acquainted with auto-immune disease and research. Only my naturopath was familiar with it but my GP looked it up and we discussed it. This was pretty much the only website I could find that has any information but I don't put a lot of credence into it because it's SO glowing, SO end-all, be-all.

    Both my GP and my naturopath said I could drink while on LDN. My GP said that it might take away any buzz (which isn't my goal with a glass of wine anyway) but that it wouldn't hurt me.

    I discussed the side effects with my GP and he said that they were based on much higher doses and also they couldn't be sure the side effects were really due to the Naltrexone because so many of the listed side effects were likely due to the fact that the drug is given to people who have OD'd on serious drugs (Naltrexone is given in high doses to basically bring them back to life). In other words, are the listed side effects due to Naltrexone or the fact that the user suffered a massive OD and nearly died?

    I began LDN treatment on June 19, taking 1.5mg capsule every night before bed for 7 days.
    Then I upped to 2 capsules every night before bed for 7 days.
    I'm now currently taking 3 capsules and will do that for 14 days before I check back in with my naturopath who wrote the prescription.

    I wish I could say that it's had any effect on me but so far, nothing. My naturopath said that in most cases, the effects were minimal but she was willing to try it. Since beginning the treatment, it did occur to me that if LDN was really all that its proponents claim, why hasn't the drug company that produces it done studies and marketed it that way -- as if a pharmaceutical company would give up the opportunity to make millions using a drug they've already developed.

    At any rate, I'm not through my 14 days but I figured I now had enough experience that it was worth writing about. I'll update when I've finished my prescription and then again when I've spoken to my doctor if there's anything more to add.

    LDN is not covered by insurance, at least not in the U.S., for those wondering.

  • #2
    Hi Potatocakes.
    I don't know about taking it orally, but there is a study underway at a hospital not too far from me on naltrexone eye drops, how they may help diabetics with cornea problems and also it's effect on dry eye. They are currently looking for volunteers for a clinical trial. So, there may be something to this. the study is being run by a Dr. Sassani at Hershey Medical Center in Hershey Pa.


    • #3
      bunnyrabbit123 - Interesting. I'll check into that. I wonder how they feel it can help. Orally, it's supposed to help by blocking certain things (sorry, the whole thing escapes me right now) but it wouldn't be the same with application directly to the eye. I wonder if there's some receptor they feel it can reach that way.


      • #4
        Last night was my last dose of LDN. I feel pretty comfortable saying that it didn't have any effect on my dry eyes.

        Forgot to mention in my first post that one of the side effects of LDN can be very vivid dreams. I did not experience vivid dreams at all. Nor did it help me sleep, which apparently it does for some people.


        • #5
          LDN only meant for Auto-immune related diseases!

          May I ask what is the underlying cause to your dry eye? LDN is supposedly meant for auto-immune related diseases I.e. Sjogren's. It is not meant to "cure" dry eye instead it is an immune modulator helping your body mechanism to heal yourself. It would have no effect otherwise. Also, not everyone will have symptom relief, but instead, most of us are just wishing for halt in disease progression.

          If your dry eye is auto-immune based, I would encourage you to give it a long enough trial. It is NOT a quick fix.

          Chris C
          Last edited by painintheeye; 21-Jul-2011, 01:31. Reason: Misspelling


          • #6
            We're not exactly sure what is causing my dry eye (I have not had Lasik or anything like it). One of my specialists is convinced I have Sjogren's and while I don't believe I have Sjogren's (no mouth issues and I blood test negative), it does seem likely it is auto-immune related for a number of reasons.

            You mention a long enough trial; what do you consider a long enough trial? My naturopath prescribed the quantity based on her past experience -- I'm not sure what else to go on without additional information.

            Thank you.


            • #7
              I can't really advice you on that because I had good result in terms of my salivary gland. As for dry eye relief, I felt improvement initially but was not consistent. LDN failed me a couple of times and I was really really scared because all the SS related symptoms returned. Fortunately I was able to address these issues and readjusted my dosages (metabolism problem) that I am now more comfortable in publishing my story after almost 4 years of using it.

              Personally I would at least give it 3-6 months before I give up. There are research papers out there that showed how LDN has been effective in some auto immune related diseases. For me, LDN gave my life back. There are a good number of days now that I can almost forget that I have SS and I am grateful for the relief and most importantly, I think I have managed to put my disease on hold for the time being. I don't know what the future will be but I will be taking it for as long as I live because it has been the only treatment that is not harmful or weaken my immune system.

              Good luck,

              Chris C


              • #8
                This is from the consent form from the BFS. I'm considering heading to Boston to try this out.

                "Naltrexone has been approved by the FDA for the treatment of opiate addiction for decades. More recently is has been used off-label in much lower doses for the treatment of a wide range of medical disorders.

                This effects of this drug in the form of very dilute eye drops has been 'studied by Professor Ian Zargon at Penn State Hershy College of Medicine on models of dry eye disease and corneal ulcers of the cornea in rats and rabbits for 30+ years in rats and rabbits. Dr. Zargon, in very extensive studies, has shown that this has no deleterious effect on animal eyes and has shown effectiveness in the treatment of non-healing corneal surface defects and dry eyes. Based on this work, the Department of Ophthalmology at the Penn College of Medicine is currently doing a study in human subjects financed by the department of defense.

                The rational for the use of these eye drops is based on the findings that our body produces a form of opiate called endorphins and that these act on the surface cells of the cornea to slow down growth and repair of corneal tissue. By blocking this effect, naltrexone eye drops supports increased metabolism of the corneal cells and may improve the function of the nerves in the surface cells of the cornea.

                Although the drug is highly diluted and has been shown to cause no adverse effects on the eyes of animals at much higher concentrations that are being used in this study, there have been no long-term studies of its use in human eyes."
                FOR WE WALK BY FAITH, NOT BY SIGHT (2 Corinthians 5:7).