Interesting pdf booklet on mechanisms of Rosacea

[y-gwair]

Interesting pdf booklet on the neuro-vascular mechanisms of Rosacea. Mainly about cutaneous rosacea but, as the same processes also underlie our sore eyes it's useful to know what triggers the whole horrible process.

Think Rosacea is a microbial problem? The warm room flush phenomenon.

[littlemermaid]

Y-gwair: Thanks for this.

LM has had obvious temperature regulation problems since a virus the week before dry eye started - very blue nose and extremities in snow, ice-cold hands even in summer. She was pre-rosacea with slight acne 1y after dry eye started, diagnosed by genius doc. Acne rosacea mask esp nose now 2y later, obvious rosacea flush has just started last 6m.

Absolutely NO sign of temperature regulation problems before virus, in fact warm and cuddly.

Neuropeptide behaviour on temperature changes -> angiogenesis makes sense for us. Interested in these anti-inflammatories but don't understand what the plan is here:

Australian Sciences has conducted extensive research into the normalization of inflammatory skin cells with natural compounds such as silymarin, egcg, vitamin B12 and many others. Independent research has also showed these compounds to be effective for other inflammatory skin disorders such as atopic dermatitis and psoriasis. We believe these products can help normalize skin cells and assist in the long-term reversal of excessive skin infrastructure.

[y-gwair]

No, I don't understand either - would be useful to have included some references. I'd guess he is planning some product down the line that he doesn't want to give to much away about.

Oxford Derm agrees with Chu, entirely vascular problem, probably related to Raynaud's phenomenon (not a hint of any allergic or chemical sensitivity). Nice to have agreement, but it doesn't really help very much given the limited interventions. It does make me wonder if all the hot/cold compressing is doing more good than harm for MGD (in the instances where glands aren't actually blocked with thickened meibum).

[littlemermaid]

I know, ma'am, but we have almost total control and clear MGs with topical antibacterials face mask - erythromycin, clindamycin, BAK, fusidic acid - and lid margins - chloramphenicol, fucithalmic - immediate improvement response, cannot skip night or day or there is immediate inflammation and reinfection. This suggests hypersensitivity to eg bacterial enzymes, periorificial only in LM's case, which reduces when eg staph is reduced; or suppression of hypersensitive response by antibacterials, who knows how.

And I'm remembering your inflammation on eyedrops. What if it's a hypersensitivity response? Good point on hot/cold compressing - Dr L is saying why express what you need unless there's blockage - but LM needs to warm eyelids to clear blocked glands and prevent further bacterial build-up, although as Dr L says, warm shower does the job well.

Chu is also adamantly anti-diet (he has an NY alter-ego diet theorist, I'll give you the name when I remember it) and totally oral systemics for treating vascular response, this is why we're not communicating too well because we can't use oral. But for your aetiology, sounds excellent.