Table 2.
A Modified Delphi Technique to Obtain Consensus on the Treatment of Dry Eye Disease
Severity Level & Signs & Symptoms
-- Recommended Treatment
1. Mild-to-moderate symptoms & no signs
Mild-to-moderate conjunctival signs
--Patient counseling, preserved tears,
environmental management, allergy eye drops,H2O intake, hypoallergenic products.
If NI,add level 2.
2. Moderate-to-severe symptoms
Tear film signs
Mild corneal punctate staining
Conjunctival staining
Visual signs
--Unpreserved tears, gels, ointments, topical
cyclosporine A (0.05%, 0.2%, 0.5%, 1.0%),
secretagogues (i.e. Pilocarpine),
topical steroids (i.e. fluorometholone), nutritional support ( i.e. flaxseed oil).
If NI, add level 3.
3. Severe symptoms
Marked corneal punctate staining
Central corneal staining
Filamentary keratitis:
--Tetracycline, punctal plugs
If NI, add level 4
4. Severe symptoms
Severe corneal staining, erosions
Conjunctival scarring:
--Systemic anti-inflammatory therapy ( i.e. oral corticosteroids), oral cyclosporine, moisture goggles, acetylcysteine (topical and oral),
punctal cautery, surgery
At least one sign and one symptom of each category should be present to qualify for corresponding level assignment.
Adapted from Behrens A, et al. Cornea. 2006;22:61-66.
A Modified Delphi Technique to Obtain Consensus on the Treatment of Dry Eye Disease
Severity Level & Signs & Symptoms
-- Recommended Treatment
1. Mild-to-moderate symptoms & no signs
Mild-to-moderate conjunctival signs
--Patient counseling, preserved tears,
environmental management, allergy eye drops,H2O intake, hypoallergenic products.
If NI,add level 2.
2. Moderate-to-severe symptoms
Tear film signs
Mild corneal punctate staining
Conjunctival staining
Visual signs
--Unpreserved tears, gels, ointments, topical
cyclosporine A (0.05%, 0.2%, 0.5%, 1.0%),
secretagogues (i.e. Pilocarpine),
topical steroids (i.e. fluorometholone), nutritional support ( i.e. flaxseed oil).
If NI, add level 3.
3. Severe symptoms
Marked corneal punctate staining
Central corneal staining
Filamentary keratitis:
--Tetracycline, punctal plugs
If NI, add level 4
4. Severe symptoms
Severe corneal staining, erosions
Conjunctival scarring:
--Systemic anti-inflammatory therapy ( i.e. oral corticosteroids), oral cyclosporine, moisture goggles, acetylcysteine (topical and oral),
punctal cautery, surgery
At least one sign and one symptom of each category should be present to qualify for corresponding level assignment.
Adapted from Behrens A, et al. Cornea. 2006;22:61-66.
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