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Here we go again....
My ophthalmologist and I were discussing the Hyaluronic Acid drops that I'm using. It turns out that there's another ingredient that ophthalmologists have been working with as a surgical "viscoelastic:" chondroitin sulfate.
My doc just got back from a lecture yesterday where a world-renowned corneal surgeon told him that
I looked in the cabinet and ... sure enough ... I have some. I've started taking it today. There seems to be some science behind the notion.
(never realized that poor bunnies had dry eyes, too
)
----
http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum
Effects of various lubricants on corneal surface regularity in rabbits.
Hirai S, Kawahara M, Sakamoto K, Kimura A, Nakamura M.
Research and Development Center, Santen Pharmaceutical Co., Ltd., Nara, Japan. shinichiro.hirai@santen.co.jp
The aim of this study was to establish a method for analysis of tear film stability and thereby to investigate the effects of lubricants on corneal surface regularity and corneal epithelial damage in anesthetized rabbits with the eye held open. Saline-instilled and noninstilled eyes manifested a time-dependent increase in the corneal surface regularity index (SRI). In contrast, 0.1% hyaluronic acid (HA) prevented the increase in the SRI for up to 20 min after instillation. Methylene blue uptake into the damaged cornea was significantly greater in eyes that received saline than in those treated with HA. Whereas eyes instilled with 0.5% methylcellulose (MC) or 0.35% sodium carboxymethylcellulose (CMC) manifested an increase in the SRI similar to that apparent in those that received saline, 1.0% chondroitin sulfate (CS) prevented the increase in the SRI for up to 10 min after instillation. In conclusion, we have established a method for analysis of tear film stability in rabbits. Our results suggest that tear film stability is closely related to corneal surface damage and that topical instillation of 0.1% HA or 1.0% chondroitin sulfate warrants further investigation as a potential treatment for patients with dry eye.
My ophthalmologist and I were discussing the Hyaluronic Acid drops that I'm using. It turns out that there's another ingredient that ophthalmologists have been working with as a surgical "viscoelastic:" chondroitin sulfate.
My doc just got back from a lecture yesterday where a world-renowned corneal surgeon told him that
his patients using
glucosamine/chondroitin tablets orally for other reasons had the best
looking corneas and best looking lasik flaps he'd ever seen. Its
anecdotal, but the meds are generally harmless. I take them!
glucosamine/chondroitin tablets orally for other reasons had the best
looking corneas and best looking lasik flaps he'd ever seen. Its
anecdotal, but the meds are generally harmless. I take them!
(never realized that poor bunnies had dry eyes, too
)----
http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum
Effects of various lubricants on corneal surface regularity in rabbits.
Hirai S, Kawahara M, Sakamoto K, Kimura A, Nakamura M.
Research and Development Center, Santen Pharmaceutical Co., Ltd., Nara, Japan. shinichiro.hirai@santen.co.jp
The aim of this study was to establish a method for analysis of tear film stability and thereby to investigate the effects of lubricants on corneal surface regularity and corneal epithelial damage in anesthetized rabbits with the eye held open. Saline-instilled and noninstilled eyes manifested a time-dependent increase in the corneal surface regularity index (SRI). In contrast, 0.1% hyaluronic acid (HA) prevented the increase in the SRI for up to 20 min after instillation. Methylene blue uptake into the damaged cornea was significantly greater in eyes that received saline than in those treated with HA. Whereas eyes instilled with 0.5% methylcellulose (MC) or 0.35% sodium carboxymethylcellulose (CMC) manifested an increase in the SRI similar to that apparent in those that received saline, 1.0% chondroitin sulfate (CS) prevented the increase in the SRI for up to 10 min after instillation. In conclusion, we have established a method for analysis of tear film stability in rabbits. Our results suggest that tear film stability is closely related to corneal surface damage and that topical instillation of 0.1% HA or 1.0% chondroitin sulfate warrants further investigation as a potential treatment for patients with dry eye.
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