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Omega-3 IN the Eye?

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  • Omega-3 IN the Eye?

    Hi, fish-oil lovers! This article in Review of Ophthalmology is kind of interesting:

    Fatty Acid Treatment May Relieve Dry Eye

    While still in early stages of testing, researchers in Boston and Genoa, Italy, found that topical administration of omega-3 and omega-6 fatty acids led to a significant decrease in dry-eye signs and inflammatory changes at both cellular and molecular levels in a mouse model.

    Formulations containing alpha-linolenic acid (ALA) and linoleic acid (LA), combined ALA and LA, or vehicle alone, were applied to dry eyes induced in mice. A masked observer assessed fluorescein staining and the number and maturation of corneal CD11b+ cells in the different treatment groups. Real-time polymerase chain reaction was used to quantify expression of inflammatory cytokines in the cornea and conjunctiva.

    Dry-eye induction significantly increased corneal fluorescein staining; CD11b+ cell number and major histocompatibility complex Class II expression; corneal IL-1 and tumor necrosis factor (TNF-alpha) expression; and conjunctival IL-1, TNF-alpha, interferon, IL-2, IL-6 and IL-10 expression. Treatment with ALA significantly decreased corneal fluorescein staining compared with both vehicle and untreated controls. Additionally, ALA treatment was associated with a significant decrease in CD11b+ cell number, expression of corneal IL-1 and TNF-alpha, and conjunctival TNF-alpha.

    They conclude that topical application of ALA omega-3 fatty acid may be a novel therapy to treat the clinical signs and inflammatory changes accompanying dry-eye syndrome.

    (Arch Ophthalmol 2008;126:219-225.)

    Rashid S, Jin Y, Ecoiffier T, Barabino S, Schaumberg D, Dana, R.

  • #2
    hi Liz
    I think the article is what Michael Lange OD is refering to..

    http://dryeyezone.com/talk/showthread.php?t=5613

    I would like to see this available to try sooonnnnn.....

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    • #3
      Thanks!

      Thanks, why!

      --Liz

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