Doxy dosage?

[JJ75]

I have MGD and have been on 50mg of Doxy 2/day for over a year now. Just came back from the doc and he gave me a prescription for 20mg once a day. Anyone else taking doxy at this low dosage? It seems like a dramatic decrease to me and I'm wondering if anyone knows if it will still be effective?

[SusieD]

I am on 100mg/day of doxy at the moment - I worry about lower dosages with antibiotics, in particular because arent you more prone to developing resistance - was 50mg working out for you?

[JJ75]

The 50 twice a day has been working. He insists that I won't notice a difference going down to 2o once a day. I'm very skeptical and a bit worried.

[neil0502]

You should be just fine....

The effect of low-dose doxycycline therapy in chronic meibomian gland dysfunction.
Seo-Eun Yoo, Dong-Cho Lee, Moo-Hwan Chang
PURPOSE: The aim was to investigate the effect of low dose doxycycline (20 mg) therapy in patients with chronic meibomian gland dysfunction that were refractory to conventional therapy. METHODS: The randomized prospective study enrolled 150 patients (300 eyes) who have chronic meibomian gland dysfunction and who didn't respond to lid hygiene and topical therapy for more than 2 months. All topical therapy was stopped for at least 2 weeks prior to beginning the study. After conducting the tear break up time test (TBUT) and Schirmer test, the authors randomly divided the patients into three groups a high dose group (doxycycline, 200 mg, twice a day), a low dose group (doxycycline, 20 mg, twice a day) and a control group (placebo). After one month, the author repeated the TBUT and Schirmer tests, and analyzed the degree of symptomatic improvement. RESULTS: Compared to the control group, both the high and low dose group showed statistically significant differences after treatment in TBUT, Schirmer test, the number of symptoms reported and the degree of improvement of subjective symptoms. However, there was no statistically significant difference between the high and low dose group after treatment in TBUT (9.42 +/- 2.87 sec, 9.54 +/- 1.58 sec, p=0.726), Schirmer test (19.98 +/- 4.05 mm, 19.65 +/- 5.02 mm, p=0.624), the number of symptoms reported (1.45 +/- 0.62, 1.53 +/- 0.52, p=0.304), as well as the degree of improvement of subjective symptoms (p=0.288). The high dose group (18 patients, 39.13%) reported side effects more frequently than did the low dose group (8 patients, 17.39%) (P=0.002). CONCLUSIONS: Low dose doxycycline (20 mg twice a day) therapy was effective in patients with chronic meibomian gland dysfunction that were refractory to conventional therapy.
Korean J Ophthalmol. 2005 Dec ;19:258-63

RETRIEVED FROM: http://lib.bioinfo.pl/auth:Lee,DC
ALSO SEE: http://www.clspectrum.com/article.aspx?article=12942

[SusieD]

There you go.......

Thanks Neil.

[Lucy]

I started taking doxycycline (again) at 50 mg 1 x day. That's probably what my doc was referring to when he was detailing something "low dose twice a day."