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I'm inclined to say that it does expire, or at least loses a lot of its potency after the expiration date. I've been using Restasis for almost 2 years. Because I get 3-4 doses out of each vile, a 30 count package lasts me about 3 months. I ended up having a package with an expiration date of October of 2010 that I continued using thinking it couldn't make THAT much difference. I suppose that's why when I started having more issues with dryness and found found myself pulling out lubricating drops during the day (which I haven't had to do in quite some time), it didn't at first occur to me that it could be related to the expiration date. When I moved on to my next refill (exp. Oct. 2012) and experienced the burning sensation I think most of us go through when we first start using Restasis (something else I haven't had in quite some time!), it had to think maybe that last package really was past its prime. I've only been using the new stuff for 2 weeks, but I can already tell a significant improvement in my eyes, and haven't had to use any lubricating drops this week. I know some people here have expressed doubts that Restasis works or accomplishes any significant relief, but in my case I will say it definitely does make a difference. But I wouldn't recommend using it too far past an expiration date. I don't think it did me any harm, but it certainly didn't do me any good either.
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