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http://www.ncbi.nlm.nih.gov/pubmed/23035891
Contact Dermatitis. 2012 Oct 5. doi: 10.1111/j.1600-0536.2012.02169.x.
[Epub ahead of print]
Patch testing with 2.0% (0.60 mg/cm(2) ) formaldehyde instead of 1.0% (0.30 mg/cm(2) ) detects significantly more contact allergy.
Pontén A, Aalto-Korte K, Agner T, Andersen KE, Giménez-Arnau AM, Gonçalo M, Goossens A, Johansen JD, Le Coz CJ,Maibach HI, Rustemeyer T, White IR, Bruze M.
Source
Department of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, 205 02 Malmö, Sweden Finnish Institute of Occupational Health, Health and Work Ability, Control of Hypersensitivity Diseases, Topeliuksenkatu 41 a A, FI-00250 Helsinki, Finland Department of Dermatology, University of Copenhagen, Bispebjerg Hospital, 2400 Copenhagen, Denmark Department of Dermatology and Allergy Centre, Odense University Hospital, University of Southern Denmark, DK-5000 Odense C, Denmark Department of Dermatology, Hospital del Mar and Univeristat Autònoma of Barcelona, 08003 Spain Department of Dermatology, Coimbra University Hospital, 3000-075 Coimbra, Portugal Department of Dermatology, University Hospital, Katholieke Universiteit Leuven, 3000 Leuven, Belgium Department of Dermato-Allergology, National AllergyResearch Centre, Copenhagen University Hospital Gentofte, DK-2900 Gentofte, Denmark Cabinet de Dermatologie and Laboratoire de Dermatochimie, 4 rue Blaise Pascal, 67070 Strasbourg Cedex, France Department of Dermatology, School of Medicine, University of California San Francisco, San Francisco, CA 94143-0989, USA Department of Dermatology, VU University Medical Centre, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands St John's Institute of Dermatology, St Thomas' Hospital, London SE1 7EH, UK.
Abstract
Background.
The currently used patch test concentration for formaldehyde is 1.0% (wt/vol) in water. However, clinical experience and previous studies suggest that 1.0% might be insufficient for detecting an optimized number of clinically relevant cases ofcontact allergy to formaldehyde.
Objectives.
To validate earlier patch test results for comparison of 1% (wt/vol) and 2% (wt/vol) formaldehyde in water, and to investigate co-reactivity with quaternium-15. Materials and methods.In 12 dermatology clinics, 3591 patients were routinely patch tested simultaneously with 2.0% (wt/vol) (0.60 mg/cm(2) ) and 1.0% (wt/vol) (0.30 mg/cm(2) ) formaldehyde. Micropipettes were used for delivering the exact dosage of the allergen.
Results.
Significantly more patients reacted to 2.0% formaldehyde than to 1.0% (3.4% versus 1.8%, p < 0.001). Overall, there were no sex differences between those reacting positively to 2.0% and 1.0%. Of 25 quaternium-15-positive patients, 4 (0.1%) reacted positively without reacting to formaldehyde.
Conclusion.
On the basis of the results of this multicentre study, as well as of previous studies, it can be suggested that 2.0% (wt/vol) in water formaldehyde should be used in routine patch testing in the baseline series.
23035891
[PubMed - as supplied by publisher]
Contact Dermatitis. 2012 Oct 5. doi: 10.1111/j.1600-0536.2012.02169.x.
[Epub ahead of print]
Patch testing with 2.0% (0.60 mg/cm(2) ) formaldehyde instead of 1.0% (0.30 mg/cm(2) ) detects significantly more contact allergy.
Pontén A, Aalto-Korte K, Agner T, Andersen KE, Giménez-Arnau AM, Gonçalo M, Goossens A, Johansen JD, Le Coz CJ,Maibach HI, Rustemeyer T, White IR, Bruze M.
Source
Department of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, 205 02 Malmö, Sweden Finnish Institute of Occupational Health, Health and Work Ability, Control of Hypersensitivity Diseases, Topeliuksenkatu 41 a A, FI-00250 Helsinki, Finland Department of Dermatology, University of Copenhagen, Bispebjerg Hospital, 2400 Copenhagen, Denmark Department of Dermatology and Allergy Centre, Odense University Hospital, University of Southern Denmark, DK-5000 Odense C, Denmark Department of Dermatology, Hospital del Mar and Univeristat Autònoma of Barcelona, 08003 Spain Department of Dermatology, Coimbra University Hospital, 3000-075 Coimbra, Portugal Department of Dermatology, University Hospital, Katholieke Universiteit Leuven, 3000 Leuven, Belgium Department of Dermato-Allergology, National AllergyResearch Centre, Copenhagen University Hospital Gentofte, DK-2900 Gentofte, Denmark Cabinet de Dermatologie and Laboratoire de Dermatochimie, 4 rue Blaise Pascal, 67070 Strasbourg Cedex, France Department of Dermatology, School of Medicine, University of California San Francisco, San Francisco, CA 94143-0989, USA Department of Dermatology, VU University Medical Centre, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands St John's Institute of Dermatology, St Thomas' Hospital, London SE1 7EH, UK.
Abstract
Background.
The currently used patch test concentration for formaldehyde is 1.0% (wt/vol) in water. However, clinical experience and previous studies suggest that 1.0% might be insufficient for detecting an optimized number of clinically relevant cases ofcontact allergy to formaldehyde.
Objectives.
To validate earlier patch test results for comparison of 1% (wt/vol) and 2% (wt/vol) formaldehyde in water, and to investigate co-reactivity with quaternium-15. Materials and methods.In 12 dermatology clinics, 3591 patients were routinely patch tested simultaneously with 2.0% (wt/vol) (0.60 mg/cm(2) ) and 1.0% (wt/vol) (0.30 mg/cm(2) ) formaldehyde. Micropipettes were used for delivering the exact dosage of the allergen.
Results.
Significantly more patients reacted to 2.0% formaldehyde than to 1.0% (3.4% versus 1.8%, p < 0.001). Overall, there were no sex differences between those reacting positively to 2.0% and 1.0%. Of 25 quaternium-15-positive patients, 4 (0.1%) reacted positively without reacting to formaldehyde.
Conclusion.
On the basis of the results of this multicentre study, as well as of previous studies, it can be suggested that 2.0% (wt/vol) in water formaldehyde should be used in routine patch testing in the baseline series.
23035891
[PubMed - as supplied by publisher]