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Treatment with daidzin suppresses the expressions of IL6 and MMP9, which was increased in the dye eye. These result suggested that daidzin improves the dry eye syndrome.
Effect of daidzin was not suppresses the expression of PGS2 in CEPI cells. This suggested that in cellular extract daidzin was dissociated from PGS. Thus the study concludes that daidzin inhibits the activity of PGS through competitive inhibition. Its effect on tyrosine radicals were also assessed in the investigation. It was observed that daidzin posses tyrosine radical scavenging activity and tyrosine radical was essential for the activity of PGS (Miura, 2012b). Hence, there was a relation between tyrosine radical scavenger and PGS inhibitor confirmed. It means that daidzin inhibits the activity of PGS on the basis of its tyrosine radical scavenging activity. Moreover there were no alteration in the expressions of TNF-α found with vehicle and daidzin treatment than normal. Treatment with daidzin was partially recovers the tear secretion in dry eye rat model.
Effect of daidzin was not suppresses the expression of PGS2 in CEPI cells. This suggested that in cellular extract daidzin was dissociated from PGS. Thus the study concludes that daidzin inhibits the activity of PGS through competitive inhibition. Its effect on tyrosine radicals were also assessed in the investigation. It was observed that daidzin posses tyrosine radical scavenging activity and tyrosine radical was essential for the activity of PGS (Miura, 2012b). Hence, there was a relation between tyrosine radical scavenger and PGS inhibitor confirmed. It means that daidzin inhibits the activity of PGS on the basis of its tyrosine radical scavenging activity. Moreover there were no alteration in the expressions of TNF-α found with vehicle and daidzin treatment than normal. Treatment with daidzin was partially recovers the tear secretion in dry eye rat model.
5. Conclusion
Thus present study concludes that treatment with daidzin protects the cornea in dry eye rat model by suppression inflammation and oxidative stress.
Thus present study concludes that treatment with daidzin protects the cornea in dry eye rat model by suppression inflammation and oxidative stress.