Dry eye Medication list

[mbperso]

Several threads are discussing about different drugs.
I found this interesting list to discuss about it:

[mbperso]

After reading this tab, the question is : what are cytokines, prostaglandin, T-cell, and how to know which one is relevant

[MGD1701]

Thanks for the useful data.
Perhaps good to know that doxy can thin the oil too, according to my (Uni.) doctor/professor. Bit surprised it does not include such function.

[mbperso]

Hi MGD1701 ,

Yes you right, I remember I read a study on ncbi site with images (experiment on mouse) which explained the oil start becoming more fluid after 10 days and good result after 29 days

[mbperso]

Seems azithromycin is better than doxy, explained in this study. (should we change ?)

Oral azithromycin versus doxycycline in MGD
https://www.ncbi.nlm.nih.gov/pubmed/25138765

CONCLUSIONS:
Although both oral azithromycin and doxycycline improved the symptoms of MGD, 5-day oral azithromycin is recommended for its better effect on improving the signs, better overall clinical response and shorter duration of treatment

[deep_dry_eye]

Seems azithromycin is better than doxy, explained in this study. (should we change ?)

Oral azithromycin versus doxycycline in MGD
https://www.ncbi.nlm.nih.gov/pubmed/25138765

CONCLUSIONS:
Although both oral azithromycin and doxycycline improved the symptoms of MGD, 5-day oral azithromycin is recommended for its better effect on improving the signs, better overall clinical response and shorter duration of treatment

While my personal belief is that azithromycin works very well in MGD, and much better than doxy. I wouldn't read too much into that paper. The research is out of Iran and not a top US/EU university.

[Guest]

Thanks for the useful data.
Perhaps good to know that doxy can thin the oil too, according to my (Uni.) doctor/professor. Bit surprised it does not include such function.

Well, the idea is that if the medication limits inflammation and reduces bacterial load, you will have a thinner oil. What's happening is the inflammation is making the gland malfunction, so fresh clean oil doesn't get in the gland and expressed out....the bacteria inside the gland eat the oil you do have and the byproduct is the thick oil. The thick oil is the waste product of the bacteria. So when you limit those two things, oil thins.

If you can thin the oil and stay ahead of the bacterial load mechanically with heat and expression, then that's way better than taking an antibiotic. But when things are bad and compresses don't cut it, time for doxy. My dr still prefers doxy as the gold standard for lid disease.

So my point is, all these products improve oil quality. Great list thanks for posting!

[mbperso]

While my personal belief is that azithromycin works very well in MGD, and much better than doxy. I wouldn't read too much into that paper. The research is out of Iran and not a top US/EU university.

I suppose you tried both, which form of azithromycin, oral or drop ?
Is treatment of 5 days enough or should it be taken again later ?


I found those articles from US universities:
Topical azithromycin and oral doxycycline
https://www.ncbi.nlm.nih.gov/pubmed/22668581

Can tetracycline duplicate ability of azithromycin to stimulate MG
https://www.ncbi.nlm.nih.gov/pubmed/25611398

[deep_dry_eye]

I suppose you tried both, which form of azithromycin, oral or drop ?
Is treatment of 5 days enough or should it be taken again later ?


I found those articles from US universities:
Topical azithromycin and oral doxycycline
https://www.ncbi.nlm.nih.gov/pubmed/22668581

Can tetracycline duplicate ability of azithromycin to stimulate MG
https://www.ncbi.nlm.nih.gov/pubmed/25611398

I tried both oral doxy and topical azithromycin. I went on 2 wk treatment of topical azithromycin (Azyter, not AzaSite; Azyter is preservative and available in the EU), however, I started feeling the effects after 1-2 days.

Many ppl on this forum posted on going on pulsed azithromycin, however it is difficult to source topical azithromycin in Canada and hence i have stopped treatment.