Brimonidine a potential therapy for MGD ( DED Study With Brimonidine is ongoing )

[bobXfr]

Articale : "DIVING INTO THE 2018 DRY EYE PIPELINE"

They found that adrenergic agonists, especially at physiological levels, are beneficial for human meibomian gland epithelial cell function; however, at higher concentrations, this effect is lost.

see: https://www.clspectrum.com/issues/20...-eye-dx-and-tx

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Clinical study :

here : https://clinicaltrials.gov/ct2/show/NCT03418727

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Article : " Effect of brimonidine, an α2 adrenergic agonist, on human meibomian gland epithelial cells. "
here : https://www.ncbi.nlm.nih.gov/pubmed/?term=brimonidine+meibomian

Our findings demonstrate that brimondine treatment induces a dose-dependent decrease in Akt signaling and proliferation of iHMGECs. In contrast, brimonidine also promotes a dose-dependent differentiation of iHMGECs, including an increase in neutral lipid, phospholipid and lysosome levels. These effects were paralleled by an inhibition of p38 signaling, and duplicated by cellular exposure to clonidine, but not phenylephrine. Brimonidine also enhanced the cellular content of sterol regulatory binding protein-1, a master regulator of lipid synthesis. Of particular interest, the putative α2 antagonists, RX821002 and MK912, did not interfere with brimonidine action, but rather stimulated IHMGEC differentiation. Our results support our hypothesis and demonstrate that α2 adrenergic agonists act directly on iHMGECs. However, these compounds do not elicit an overall negative effect. Rather, the α2 agonists promote the differentiation of iHMGECs

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Article :Certain Anti-glaucoma Drugs Impact Meibomian Gland Epithelium

see : https://www.reviewofoptometry.com/news/article/certain-antiglaucoma-drugs-impact-meibomian-gland-cells

The findings demonstrated that brimondine treatment induced proliferation and differentiation of MG epithelial cells, including an increase in neutral lipid, phospholipid and lysosome levels, researchers said.¹

Of particular interest, the putative α2 antagonists RX821002 and MK912 did not interfere with brimonidine action, but instead stimulated MG cell differentiation, researchers said.

Overall, the researchers were surprised to find these anti-glaucoma compounds promoted the differentiation of cells rather than eliciting an overall negative effect, as was expected.

[bobXfr]

Promising, i think

[Hokucat]

bobXfr , this interests me, as last year I was on Brimonidine (Alphagan P) plus another drop for a suspected eye condition, and I often thought my eyes felt better while on these drops. But I asked my retina specialist to switch me to preservative free drops, and when he did, it was to something else, not Brimonidine...I feel like on these other drops, my eyes don’t feel quite as good, but was thinking it was just my imagination until I saw your post. I will be keeping a look out for more research on this. Thank you for this info!

[bobXfr]

Hokucat may be you are right, wait and see, the study is ongoing.