I mean WTF is going on lol!

When my eyes are really inflamed they might burn a bit with muro. But same with coconut oil or whatever. It doesnt feel uncomfortable for very long

Thanks, I hope that eye heals up soon. So sorry that happened to you.

[edmunder]

When my eyes are really inflamed they might burn a bit with muro. But same with coconut oil or whatever. It doesnt feel uncomfortable for very long

Hmm. I started using it recently because i have a mild case of map dot fingerprint dystrophy. The Muro 128 that is. I like it but its jard to clean off in the morning. Anything with white petroleum will be. I used Refresh pm once and its like putting vaseline on your eyes. Muro is much thinner and helps to hydrate the cornea surface with a sodium to draw out water to the surface - to help reduce tearing for map dot.

Anyways i like muro but do i thorough cleaning in the morning, then lid cleaning and sometimes i wake up and do warm compress to get it sll out. But not since friday. Haha

Does it burn or irritate your eye?

[edmunder]

Hmm. I started using it recently because i have a mild case of map dot fingerprint dystrophy. The Muro 128 that is. I like it but its jard to clean off in the morning. Anything with white petroleum will be. I used Refresh pm once and its like putting vaseline on your eyes. Muro is much thinner and helps to hydrate the cornea surface with a sodium to draw out water to the surface - to help reduce tearing for map dot.

Anyways i like muro but do i thorough cleaning in the morning, then lid cleaning and sometimes i wake up and do warm compress to get it sll out. But not since friday. Haha

[Glucoa]

I have not tried that yet...but I'm assuming that may be my next step. Does it work well for you? Any negatives?

It's an OTC ointment that is recommended by doctors to help prevent corneal abrasions. I've only used it a couple of times. It works well, but I notice it does clog the meibomian glands the next day if I apply too much before sleeping.

I'm going to try your pinky smearing tip and see if this works better.

Have you used Muro 128 ointment for night time Dowork?

I have not tried that yet...but I'm assuming that may be my next step. Does it work well for you? Any negatives?

[Glucoa]

Have you used Muro 128 ointment for night time Dowork?

How do you apply the 1cm erythromycin strip into lower eye? You mean lower eyelid? Do you do this with your finger or a Q-tip? Am impressed with your guys' knowledge of these clinical studies, conflicts of interest, placebos, and other factors to look for. You need a PhD to understand these clinical trials and unfortunately since most people don't have that we have to hope our docs are interpreting it correctly on our behalf.

I clean my hands very very well, spot a strip to my pinky finger, pull lower lid down, and swipe it into the lid. I hope this new path I'm taking is helpful. I know for sure restasis was not helping me and it was most likely hurting me. I notice any drop for MGD like retaine or endura makes my eyes itch. I think restasis was doing this too and I didn't know it. I was constantly pulling my shirt up and using it to scratch my lids cause they itched. That has stopped as soon as I stopped restasis. Again, if this doesn't work out and I have to try it again, I will.

[diydry]

How do you apply the 1cm erythromycin strip into lower eye? You mean lower eyelid? Do you do this with your finger or a Q-tip? Am impressed with your guys' knowledge of these clinical studies, conflicts of interest, placebos, and other factors to look for. You need a PhD to understand these clinical trials and unfortunately since most people don't have that we have to hope our docs are interpreting it correctly on our behalf.

Just FYI I read the insert for the erythromycin, it said put a 1cm strip in lower eye...my directions from the dr say put a 1mm strip into eye...HUGE difference lol last night I was burning like crazy...so I read thevdics instructions and there we have it...putting 10x the amount in. Just FYI for anyone out there, listen to your dr lol not the insert.

[deep_dry_eye]

Oh, I understand that prokera heals the eye. But I can show you a study with the same or better findings using autologous serum. So what's the benefit of prokera over serum? Serum is hypoallergenic, 3 months is cheaper than prokera and it has similar or better effects on nerve regeneration. The study had a few conflicts of interest as well, did you see that?

Yes, conflict. Yes it's not a top rated journal.

Some patients respond to Prokera who don't respond to autologous -- i.e., AMT worked on patients where AS didn't help.

This is just another treatment option, I was on autologous for several months and I didn't notice any improvement. I am ~2 months post-op on my Prokera, and I've definitely noticed an improvement. Of course, correlation doesn't imply causation, my improvement may be placeblo, or my other treatments (Xiidra/Restasis) finally kicking in.

Here is more evidence that AMT (Prokera) can help MGD:
https://www.hindawi.com/journals/joph/2017/6404918/

Healing the nerves can increase TBUT.

Oh, I understand that prokera heals the eye. But I can show you a study with the same or better findings using autologous serum. So what's the benefit of prokera over serum? Serum is hypoallergenic, 3 months is cheaper than prokera and it has similar or better effects on nerve regeneration. The study had a few conflicts of interest as well, did you see that?

[deep_dry_eye]

Here is more evidence that AMT (Prokera) can help MGD:
https://www.hindawi.com/journals/joph/2017/6404918/

Healing the nerves can increase TBUT.

You can get topical Azithromycin compounded, but the delivery vehicle won't be as good.

My doctor only prescribes azasite for capped glands when he starts people on compress/hygiene regimen. Erythromycin is working great actually, acts as a mechanical barrier during sleep, sits on the eye longer and doesnt burn.

Its really too soon to get excited but my left eye, the one with double vision...the double vision is gone in two days...and most of it is the night ointment and protection helping the eye. So I cannnot wait to see where I'm at in a month. The doxy didn't upset my stomach at 50mg so I'm very very hopeful. I feel wayyy better not taking restasis too. But again, too soon to tell if it was helping or not but I'm happy I'm not physically putting it in my eye, I hate it lol.

edit: the erythromycin doesn't burn, but it drains down my nose and throat...super bitter. Not as bad as xiidra, but bitter and unpleasant. Also, deep dry eye is right, the gel of the original azasite is very very nice as far as delivery.

[deep_dry_eye]

There are a lot of good treatments here that warrant consideration. I have not tried Azithromycin, Xiidra, or IPL for example! However few if any of my doctors have recommended them to me, so it's up to me to bring it up (or find other doctors). I guess I am reluctant to keep trying more and more medications but some of these will be my next step, particularly IPL. Azithromycin I am concerned about BAK, I want to ask about a preservative-free option.



I'm also currently stopping restasis since being on it for over 6 months, no clear difference (and it certainly didn't help inflammation, redness continues to be a problem even when my symptoms aren't so bad). I can always go back on it, I understand the rationale for it and it has worked for many others like deep_dry_eye. I may actually try Xiidra next instead of simply going back on the Restasis since it's a different pharmaceutical mechanism of action, so one might work if the other doesn't. BTW, steroids also were HIGHLY effective for me at strong doses and I noticed that tears would come out when I yawned and even when I woke up in the middle of the night, pretty powerful stuff! But it's not a long term option, especially the dexamethasone which I used.



OK, it sounds like it's worth trying for a few months. It's hard to judge if these things work when you're in an acute state, you have to wait until you're stable. As for me, I was on it for 3 months. I didn't notice a clear difference that I could directly attribute to the doxy, but it's possible that it helped (I certainly did not get worse during that time). After getting a horrible sunburn, I asked my doctor if I could stop taking it and he said yeah, but that I might need to go back on it in another 3 or 6 months. His attitude is that doxy as well as steroids are treatments you can do in intervals or pulses if there are flareups or things seem to be getting worse. I like this approach, since taking doxy every day for the rest of my life sounds extreme and bad for my gut. Good luck!

You can get topical Azithromycin compounded, but the delivery vehicle won't be as good.