Melatonin potentiates tear secretion induced by diadenosine tetraphosphate in the rab

[sazy123]

Melatonin potentiates tear secretion induced by diadenosine tetraphosphate in the rabbit

Charles H.V. Hoyleb, , , Assumpta Perala and Jesús Pintora
aDepartamento Bioquímica, Escuela de Óptica, Calle Arcos de Jalon s/n, 28037 Madrid, Spain
bInstitute of Medicine, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong BE 1410, Brunei Darussalam
Received 16 June 2006; revised 6 September 2006; accepted 7 September 2006. Available online 22 September 2006.





Abstract

Diadenosine tetraphosphate (Ap4A, 0.03 nmol) applied topically to the cornea of New Zealand white rabbits, evoked an increase in tear secretion of 9.7 ± 2.60% (N = 7). Melatonin (1 nmol) had no significant effect. Application of Ap4A in combination with melatonin, evoked a significantly greater increase in tear secretion of 34.2 ± 5.8% (N = 11). This potentiating effect of melatonin was blocked by pretreating the cornea with a topical application of the melatonin receptor antagonist, luzindole (240 nmol). Melatonin combined with Ap4A may be useful for treating dry eye conditions.
Keywords: Melatonin; Diadenosine tetraphosphate; Dinucleotides; Melatonin receptor; P2Y receptor; Tear secretion

http://www.sciencedirect.com/science...b93c4455c34dd4

[Alexandra]

thanks sazy

hey sazy, thanks a lot for posting that! that sounds very interesting!!!!!