I'm with MGman on treating the dermatophytes feasting on the excess sebum - we've got much better control using gentle tea tree oil products as well as chronic-use topical antibacterials (in rotation, like Spmcc - currently we are using erythromycin) so there must have been overgrowth of demodex as well as bacteria. Malassezia furfur, if you see it, can be shifted with TTO but needs a gentle scrub with a loofah because mycellial strands go a little sub-cutaneous and it didn't go with TTO products (we had Tinea versicolor patches on the back and hairline during early puberty). If anyone uses an antifungal topical for Tinea, make sure there's no steroid in it because there's no need for it. Eg we're doing well with a very dilute TTO (1:50) shampoo eye clean for blepharitis although I'm wondering about taking this up a step to Dr Tseng's recipes. We're using TTO bath and shower soap, and rotating shampoo with anti-dandruff. The problem with rosacea is not to set red reaction off with some of these ingredients.
Derm advice recently was not just to rotate the gentler antibacs, but to consider building up tolerance for stronger ones, eg azelaic acid or metronidazole, by using less frequently eg 2 or 3 /wk and then increasing. We haven't done this because it's a microbiologist nightmare, but if the acne rosacea was more severe, we might.
However, none of this treats the cause. Certainly we have correlated diet triggers - gluten, sugar, dairy - but also stress and post-virus and pre-menstrual. ATM I'm thinking about gut dysbiosis and wondering about SIBO and digestive enzymes. Acne rosacea sufferers are deficient in hydrochloric acid in the stomach (they've known this since post mortems in the 1920s) but I can't get LM to drink apple cider vinegar although she likes lemon in water. This would be to alter the stomach pH to more acidic to assist normal digestive bacteria v protagonists.
Acne and rosacea are very different pathways. Rosacea seems to be a type IV hypersensitivity inflammatory disorder. Many people have success if they can identify their various triggers and I have actually met these people (http://rosaceagroup.org/new/); sometimes it's something we've consumed through childhood from habit like fruit juice or white bread. Bizarre, isn't it.
We are using a multivitamin on/off but one with trace minerals in case of deficiency, maybe through inability to process (see a well-qualified Pharmacist, some of them are really good on this type of thing). I have to say this is the first thing a vet would give after doing a swab or biopsy, after that they're thinking about systemic disorder and building the immune system.
There's a good chance some of these chronic acne/rosacea overactive immune responses were triggered by dealing with invaders or new residents - virus, bacteria, helminth (maybe don't google that...) - and an over-reaction to identifiable 'allergens' was set up (even sunlight in the case of rosacea).
All this clogs the MGs and damages the eyes with keratitis (search 'blepharoconjunctivitis or 'blepharokeratoconjunctivitis''), unfortunately. But there's a lot of work underway currently to look at various inflammatory pathways for this and other autoinflammatory disorders, thank God (see PubMed 'acne rosacea' 'acne blepharitis' etc) and some of the endocrinology journals are way ahead of derms and ophth but too detailed and specific to be useful yet, but interesting eg Journal of Hormone, Steroid and Lipid Metabolism. Therein, I feel, lies the key.
Jenny, In MGD and acne, what we're doing is trying to improve the lipids and the sebum and diet is one of the ways to do this (poor LM has what she's eaten written all over face and coming out of the MGs some days, so I know a good clean nutritious diet helps). We are listening to EyeAllergyKids on diet, esp not eating processed foods, esp not with the enemy, glucose-fructose corn syrup, (but without the enemas, lol). But you've got a lot more going on than MGD, haven't you, so health-wise you'd be building your strength, esp immune system <hug>
Despite all this trailing around the best available derms in UK, I've just finally given in and booked a naturopath to see if they have a clue what's happening, lol. I'm expecting them to say it's the thyroid-adrenal-pancreas axis (and a few more bits not working), and there's food intolerance and hypersensitivity. Yeah, but what do we do about it.
I still think using various steroids for immunosuppression, eg for acne, can trigger acne rosacea (search PubMed 'steroid acne') and in some people it hasn't rectified (this is proven for children, search PubMed 'child steroid rosacea').
Jenny, didn't your acne start after you started N Acetyl Cysteine? I'm wondering what the heck that is doing to you (mucolytic).
If it is rosacea more than acne, Tiff, you'd be looking at helping the skin maintain a good barrier with compatible moisturisers (pH neutral, perfume and paraben free etc).
Again, not a doc, not a derm. Just trying different things too, trying to work out what's gone wrong


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