Tear protein upregulation and downregulation in AD, MGD and healthy eye

[bobXfr]

Proteins identified by LC-MS/MS with the most significant changes in their expression levels in dry eye (DE), Meibomian gland dysfunction (MGD), and control (CT) groups.

UniProt

Protein name

Gene name

FDR (q-value)

FOLD

Highest mean

Lowest mean

Number of peptides

P01024	Complement C3	C3	5.66E-05	1.86	DE	CT	6
P06703	Protein S100-A6	S100A6	5.40E-08	2.26	DE	CT	2
P05109	Protein S100-A8	S100A8	1.68E-04	2.15	DE	CT	4
P00450	Ceruloplasmin	CP	3.76E-02	3.25	DE	CT	2
P05090	Apolipoprotein D	APOD	8.68E-03	3.85	DE	CT	3
P19652	Alpha-1-acid glycoprotein 2	ORM2	1.69E-04	2.13	DE	CT	4
P10599	Thioredoxin	TXN	4.14E-04	1.61	DE	MGD	3
P01857	Ig gamma-1 chain C region	IGHG1	4.14E-04	1.61	DE	MGD	10
P14555	Phospholipase A2, membrane-associated	PLA2G2A	1.77E-02	3.13	DE	MGD	7
P01009	Alpha-1-antitrypsin	SERPINA1	4.05E-03	1.98	DE	MGD	5
P03973	Antileukoproteinase	SLPI	2.32E-02	3.59	DE	MGD	3
P04083	ANXA1 protein	ANXA1	1.46E-03	1.83	MGD	CT	2
P10909	Clusterin	CLU	1.52E-02	2.68	MGD	CT	8
P02763	Alpha-1-acid glycoprotein 1	ORM1	1.75E-02	1.49	MGD	CT	4
P22079	Lactoperoxidase	LPO	1.73E-02	2.40	MGD	DE	2
Q99935	Proline-rich protein 1	PROL1	5.82E-03	1.64	CT	DE	8
O95968	Secretoglobin family 1D member 1	SCGB1D1	2.00E-02	1.63	CT	DE	5
O75556	Mammaglobin-B	SCGB2A1	3.56E-03	1.65	CT	DE	11
P31025	Lipocalin-1	LCN1	3.61E-02	1.81	CT	DE	11
P01036	Cystatin-S	CST4	3.56E-03	1.65	CT	DE	6
P12273	Prolactin-inducible protein	PIP	3.69E-02	1.9	CT	DE	8
P81605	Dermcidin	DCD	6.27E-03	2.55	CT	DE	2
P02814	Submaxillary gland androgen-regulated protein	PROL3	3.44E-02	1.61	CT	DE	4
Q08380	Galectin-3-binding protein	LGALS3BP	4.61E-02	2.64	CT	DE	2
Q9GZZ8	Extracellular glycoprotein lacritin	LACRT	2.19E-02	1.83	CT	DE	6
Q16378	Proline-rich protein 4	PRR4	3.23E-02	2.02	CT	DE	4

The fold-values shown for each protein refer to the ratios between the group with the highest mean expression values (Highest Mean) and the group with the lowest mean expression values (Lowest Mean). The number of peptides identified was filtered using the PeptideProphet probability threshold of 0.95. FDR = False discovery rate..

see : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727318/
Lacritin is downregulated in both DE and MGD
clusterin is upregulated in and MGD and DE .

[farmgirl]

I take it bob that you are an eye doctor cause all of this is Greek to me

[bobXfr]

No , not at all.but i know using well computer ;-)
Sorry, the table was truncated. i fix it know.